Anti-MAT1A Antibody Picoband®

SKU: A04203-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ICC/IF,Flow Cytometry

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry(Fixed), 1-3 μg/1x10⁶ cells, Human

Gene Name: MAT1A

Specificity:

Background: This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human MAT1A, identical to the related mouse and rat sequences.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Alvarez, L., Corrales, F., Martin-Duce, A., Mato, J. M. Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies. Biochem. J. 293: 481-486, 1993. 2. Blom, H. J., Davidson, A. J., Finkelstein, J. D., Luder, A. S., Bernardini, I., Martin, J. J., Tangerman, A., Trijbels, J. M. F., Mudd, S. H., Goodman, S. I., Gahl, W. A. Persistent hypermethioninaemia with dominant inheritance. J. Inherit. Metab. Dis. 15: 188-197, 1992. 3. Cabrero, C., Puerta, J., Alemany, S. Purification and comparison of two forms of S-adenosyl-L-methionine synthetase from rat liver. Europ. J. Biochem. 170: 299-304, 1987.

Uniprot ID: Q00266

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 50 kDa

Calculated Molecular Weight: 44 kDa

Gene ID: 4143

Protein Name: S-adenosylmethionine synthase isoform type-1

Gene Full Name: methionine adenosyltransferase 1A

Synonyms: AdoMet synthase 1; AMS1; MAT; MAT 1; MAT I/III; MAT1A; MATA1; SAMS; SAMS1