Anti-MAL Antibody Picoband®

SKU: A06941-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: WB

Application Details: Western blot, 0.25-0.5μg/ml, Human

Gene Name: MAL

Specificity:

Background: Myelin and lymphocyte protein is a protein that in humans is encoded by the MAL gene. The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MAL, identical to the related mouse and rat sequences.

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.005mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500μg/ml.

Reference: 1. Alonso, M., Barton, D. E., Francke, U. MAL, a membrane protein associated with human T-cell differentiation, is encoded on human chromosome 2, region cen-q13. (Abstract) Cytogenet. Cell Genet. 46: 570 only, 1987. 2. Alonso, M. A., Barton, D. E., Francke, U. Assignment of the T-cell differentiation gene MAL to human chromosome 2, region cen-q13. Immunogenetics 27: 91-95, 1988. 3. Alonso, M. A., Weissman, S. M. cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation. Proc. Nat. Acad. Sci. 84: 1997-2001, 1987.

Uniprot ID: P21145

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 17 kDa

Calculated Molecular Weight: 87148 MW

Gene ID: 4118

Protein Name: Myelin and lymphocyte protein

Gene Full Name: mal, T cell differentiation protein (MAL blood group)

Synonyms: mal; T cell differentiation protein; MVP17; VIP17; MAL