Anti-IRAKM/IRAK3 Antibody Picoband®

SKU: PA2207-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: WB

Application Details: Western blot, 0.1-0.5μg/ml, Human

Gene Name: IRAK3

Specificity: No cross reactivity with other proteins.

Background: Interleukin-1 receptor-associated kinase 3, also called IRAK3 or IRAKM is an enzyme that in humans is encoded by the IRAK3 gene. The IRAKM gene consists of 12 exons spanning a region of approximately 60 kb in chromosome 12q14.3. This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human IRAKM.

Clonality: Polyclonal

Contents: Each vial contains antibody formulated with stabilizing components, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
*This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Balaci, L., Spada, M. C., Olla, N., Sole, G., Loddo, L., Anedda, F., Naitza, S., Zuncheddu, M. A., Maschio, A., Altea, D., Uda, M., Pilia, S., and 30 others. IRAK-M is involved in the pathogenesis of early-onset persistent asthma. Am. J. Hum. Genet. 80: 1103-1114, 2007. 2. Deng, J. C., Cheng, G., Newstead, M. W., Zeng, X., Kobayashi, K., Flavell, R. A., Standiford, T. J. Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J. Clin. Invest. 116: 2532-2542, 2006. 3. Kobayashi, K., Hernandez, L. D., Galan, J. E., Janeway, C. A., Jr., Medzhitov, R., Flavell, R. A. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110: 191-202, 2002.

Uniprot ID: Q9Y616

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 53 kDa

Calculated Molecular Weight: 67767 MW

Gene ID: 11213

Protein Name: Interleukin-1 receptor-associated kinase 3

Gene Full Name: interleukin 1 receptor associated kinase 3

Synonyms: ASRT5; FLJ13601; IRAK 3; IRAK M; IRAK3; IRAKM