Anti-GNAO1 Antibody Picoband®

SKU: A05532-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ELISA

Application Details: Western blot, 0.1-0.25 μg/ml, Mouse, Rat
ELISA, 0.1-0.5 μg/ml, -

Gene Name: GNAO1

Specificity:

Background: Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene. The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene.

Immunogen: E.coli-derived human GNAO1 recombinant protein (Position: M1-R179).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Ananth, A. L., Robichaux-Viehoever, A., Kim, Y.-M., Hanson-Kahn, A., Cox, R., Enns, G. M., Strober, J., Willing, M., Schlaggar, B. L., Wu, Y. W., Bernstein, J. A. Clinical course of six children with GNAO1 mutations causing a severe and distinctive movement disorder. Pediat. Neurol. 59: 81-84, 2016. 2. Danti, F. R., Galosi, S., Romani, M., Montomoli, M., Carss, K. J., Raymond, F. L., Parrini, E., Bianchini, C., McShane, T., Dale, R. C., Mohammad, S. S., Shah, U., and 9 others. GNAO1 encephalopathy: broadening the phenotype and evaluating treatment and outcome. Neurol. Genet. 3: e143, 2017. Note: Electronic Article. 3. Feng, H., Sjogren, B., Karaj, B., Shaw, V., Gezer, A., Neugib, R. R. Movement disorder in GNAO1 encephalopathy associated with gain-of-function mutations. Neurology 89: 762-770, 2017.

Uniprot ID: P09471

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 40 kDa

Calculated Molecular Weight: 48608 MW

Gene ID: 2775

Protein Name: Guanine nucleotide-binding protein G

Gene Full Name: G protein subunit alpha o1

Synonyms: G ALPHA o; GNAO; GNAO1