Anti-GLUL Antibody Picoband®

SKU: A03191-3

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,ICC,IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: GLUL

Specificity:

Background: The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants.

Immunogen: E.coli-derived human GLUL recombinant protein (Position: N74-N373).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Clancy, K. P., Berger, R., Cox, M., Bleskan, J., Walton, K. A., Hart, I., Patterson, D. Localization of the L-glutamine synthetase gene to chromosome 1q23. Genomics 38: 418-420, 1996. 2. Eelen, G., Dubois, C., Cantelmo, A. R., Goveia, J., Bruning, U., DeRan, M., Jarugumilli, G., van Rijssel, J., Saladino, G., Comitani, F., Zecchin, A., Rocha, S., and 27 others. Role of glutamine synthetase in angiogenesis beyond glutamine synthesis. Nature 561: 63-69, 2018. 3. Gibbs, C. S., Campbell, K. E., Wilson, R. H. Sequence of a human glutamine synthetase cDNA. Nucleic Acids Res. 15: 6293 only, 1987.

Uniprot ID: P15104

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 42 kDa

Calculated Molecular Weight:

Gene ID: 2752

Protein Name: Glutamine synthetase

Gene Full Name: glutamate-ammonia ligase

Synonyms: GLNS; GLUL; Glutamate ammonia ligase; Glutamate decarboxylase; Glutamine synthetase; GS; PIG43; PIG59