Anti-GABBR2 Antibody Picoband®

SKU: A03830-2

Size: 100 μg

Storage: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/ml, Human
ELISA, 0.1-0.5 μg/ml

Gene Name: GABBR2

Specificity:

Background: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.

Immunogen: E.coli-derived human GABBR2 recombinant protein (Position: D100-Q889). Human GABBR2 shares 98.4% and 98.1% amino acid (aa) sequence identity with mouse and rat GABBR2, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Beuten, J., Ma, J. Z., Payne, T. J., Dupont, R. T., Crews, K. M., Somes, G., Williams, N. J., Elston, R. C., Li, M. D. Single- and multilocus allelic variants with the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. Am. J. Hum. Genet. 76: 859-864, 2005. 2. Clark, J. A., Mezey, E., Lam, A. S., Bonner, T. I. Distribution of the GABA-B receptor subunit gb2 in rat CNS. Brain Res. 860: 41-52, 2000. 3. EuroEPINOMICS-RES Consortium, Epilepsy Phenome/Genome Project, Epi4K Consortium. De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies. Am. J. Hum. Genet. 95: 360-370, 2014. Note: Erratum: Am. J. Hum. Genet. 100: 179 only, 2017.

Uniprot ID: O75899

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 106 kDa

Calculated Molecular Weight: 106 kDa

Gene ID: 9568

Protein Name: Gamma-aminobutyric acid type B receptor subunit 2

Gene Full Name: gamma-aminobutyric acid type B receptor subunit 2

Synonyms: G protein coupled receptor 51; GABA B R2; GABA B receptor 2; GABA BR2; GABABR2; GABBR2; Gb2; GPR51; GPRC3B; HG20; HRIHFB2099