Anti-ETV2 Antibody Picoband®

SKU: A08360-2

Size: 100 μg

Storage: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Mouse,Rat

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Mouse
ELISA, 0.1-0.5 μg/ml

Gene Name: ETV2

Specificity:

Background: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of endothelial cell differentiation; and positive regulation of mesoderm development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in limb ischemia. Orthologous to human ETV2 (ETS variant transcription factor 2).

Immunogen: E.coli-derived mouse ETV2 recombinant protein (Position: M1-Q335). Mouse ETV2 shares 67.4% amino acid (aa) sequence identity with human ETV2.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Basel-Salmon, L., Ruhrman-Shahar, N., Barel, O., Hagari, O., Marek-Yagel, D., Azulai, N., Bazak, L., Svirsky, R., Reznik-Wolf, H., Lidzbarsky, G. A., Shohat, M. Biallelic variants in ETV2 in a family with congenital heart defects, vertebral abnormalities and preaxial polydactyly. Europ. J. Med. Genet. 64: 104124, 2021. 2. Brown, T. A., McKnight, S. L. Specificities of protein-protein and protein-DNA interaction of GABP-alpha and two newly defined ets-related proteins. Genes Dev. 6: 2502-2512, 1992. 3. De Haro, L., Janknecht, R. Cloning of the murine ER71 gene (Etsrp71) and initial characterization of its promoter. Genomics 85: 493-502, 2005.

Uniprot ID: P41163

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 37 kDa

Calculated Molecular Weight: 37 kDa

Gene ID: 14008

Protein Name: ETS translocation variant 2

Gene Full Name: ets variant 2

Synonyms: ETV2; ER71; ETSRP71; ETS translocation variant 2; Ets-related protein 71