Anti-Dopamine beta Hydroxylase/DBH Antibody Picoband®

SKU: A01110

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: ELISA,WB

Application Details: Western blot, 0.1-0.25μg/ml, Human, Mouse, Rat
ELISA, 0.1-0.5μg/ml, -

Gene Name: DBH

Specificity: No cross reactivity with other proteins.

Background: Dopamine beta-hydroxylase  (DBH), also known as dopamine beta-monooxygenase, is an enzyme  (EC1.14.17.1) that in humans is encoded by the DBH gene. Dopamine beta-hydroxylase catalyzes the chemical reaction. It is mapped to 9q34.2. The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.

Immunogen: E.coli-derived human Dopamine beta Hydroxylase/DBH recombinant protein (Position: S40-N545).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Rush RA, Geffen LB (1980). Dopamine beta-hydroxylase in health and disease. Critical Reviews in Clinical Laboratory Sciences. 12 (3): 241–77. 2. Kaufman S, Bridgers WF, Baron J (1968). The Mechanism of Action of Dopamine beta-Hydroxylase. Advances in Chemistry. 77, chapter 73: 172–176. 3. Friedman S, Kaufman S (May 1966). An electron paramagnetic resonance study of 3,4-dihydroxyphenylethylamine beta-hydroxylase. The Journal of Biological Chemistry. 241 (10): 2256–9.

Uniprot ID: P09172

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 75 kDa

Calculated Molecular Weight: 51735 MW

Gene ID: 1621

Protein Name: Dopamine beta-hydroxylase

Gene Full Name: dopamine beta-hydroxylase

Synonyms: DBH; DBM