Anti-ANGPTL3 Antibody Picoband®

SKU: A02929

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB

Application Details: Western blot, 0.1-0.5μg/ml

Gene Name: ANGPTL3

Specificity: No cross reactivity with other proteins.

Background: ANGPTL3 (Angiopoietin-Like 3), also known as ANGPT5, is a protein which in humans is encoded by the ANGPTL3 gene. The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. By radiation hybrid mapping and the use of surrounding genes, this gene is mapped to chromosome 1p31. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human ANGPTL3, identical to the related mouse and rat sequences.

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Camenisch, G, Pisabarro, M. T., Sherman, D., Kowalski, J., Nagel, M., Hass, P, Xie, M.-H., Gurney, A., Bodary, S., Liang, X. H., Clark, K., Beresini, M, Ferrara, N., Gerber, H.-P. ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha-v-beta-3 and induces blood vessel formation in vivo. J. Biol. Chem. 277: 17281-17290, 2002. 2. Conklin, D., Gilbertson, D., Taft, D. W., Maurer, M. F., Whitmore, T. E., Smith, D. L., Walker, K. M., Chen, L. H., Wattler, S., Nehls, M., Lewis, K. B. Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics 62: 477-482, 1999. 3. Koishi, R., Ando, Y., Ono, M., Shimamura, M., Yasumo, H., Fujiwara, T., Horikoshi, H., Furukawa, H. Angptl3 regulates lipid metabolism in mice. Nature Genet. 30: 151-157, 2002.

Uniprot ID: Q9Y5C1

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 54 kDa

Calculated Molecular Weight: 79686 MW

Gene ID: 27329

Protein Name: Angiopoietin-related protein 3

Gene Full Name: angiopoietin like 3

Synonyms: ANG 5; Angiopoietin 5; angiopoietin like 3; Angiopoietin like protein 3; Angiopoietin related protein 3; ANGPT5; ANGPTL3