Androgen receptor/NR3C4 Monoclonal Antibody

SKU: AN200154P

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Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:AR

Target Synonym:HYSP;NR3C;SMAX;AIS;AR8;DHTR;HUMARA;HYSP1;KD;NR3C4;SBMA;SMAX1;TFM;AR;AIS;AR8;DHTR;HUMARA;HYSP1;KD;NR3C4;SBMA;SMAX1;TFM;AR;Group C;Member 4;Nuclear Receptor Subfamily 3

Research Areas:Signal Transduction;Epigenetics and Nuclear Signaling;Cancer;Developmental Biology

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:ICC/IF

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:1A9

UNIProt ID:P10275

Accession:

Background:The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Concentration:1 mg/mL

Immunogen:A synthetic peptide corresponding to the center region of the Human Androgen receptor/NR3C4

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:ICC/IF 1:20-1:100

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