AMFR Antibody, Biotin conjugated - Cat. #: CSB-PA333164LD01HU

SKU: CSB-PA333164LD01HU

Size :50ug

Clone Number:

Aliases:AMF receptor antibody; AMF receptor isoform 1 antibody; AMF receptor isoform 2 antibody; AMFR antibody; AMFR2_HUMAN antibody; Autocrine motility factor receptor antibody; Autocrine motility factor receptor precursor; isoform 1 antibody; Autocrine motility factor receptor precursor; isoform 2 antibody; E3 ubiquitin-protein ligase AMFR antibody; gp78 antibody; isoform 2 antibody; RING finger protein 45 antibody; RNF 45 antibody; RNF45 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UKV5

Immunogen:Recombinant Human E3 ubiquitin-protein ligase AMFR protein (485-643AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:AMFR

Research Areas:Cancer; Cell biology