AHR antibody , Cat. # FNab00231

SKU: FNab00231

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes(such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

Immunogen:aryl hydrocarbon receptor

Synonyms:Ah receptor, AHR, aryl hydrocarbon receptor, bHLHe76

Observed MW:105 kDa

Uniprot ID:P35869

Reactivity:Human, Mouse

Tested Application:ELISA, WB, IHC, IP

Recommended dilution:WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200

Gene ID:196

Research Area:Epigenetics, Signal Transduction, Metabolism