ADAM17-Specific antibody , Cat. # FNab00139

SKU: FNab00139

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:The ADAMs(A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor(TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.

Immunogen:ADAM metallopeptidase domain 17

Synonyms:ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme

Observed MW:29 kDa

Uniprot ID:P78536

Reactivity:Human

Tested Application:ELISA, WB

Recommended dilution:WB: 1:200-1:2000; IHC: 1:20-1:200

Gene ID:6868

Research Area:Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology, Neuroscience