ZAP70 (Ab-493) Antibody - Cat. #: CSB-PA447684

SKU: CSB-PA447684

Size :100ul

Clone Number:

Aliases:70 kDa zeta associated protein antibody; 70 kDa zeta-associated protein antibody; EC 2.7.10.2 antibody; FLJ17670 antibody; FLJ17679 antibody; Selective T cell defect antibody; SRK antibody; STD antibody; Syk related tyrosine kinase antibody; Syk-related tyrosine kinase antibody; Truncated ZAP kinase antibody; Tyrosine protein kinase ZAP70 antibody; Tyrosine-protein kinase ZAP-70 antibody; TZK antibody; ZAP 70 antibody; ZAP70 antibody; ZAP70_HUMAN antibody; Zeta chain associated protein kinase 70kD antibody; Zeta chain associated protein kinase 70kDa antibody; Zeta chain associated protein kinase 70kDa isoform 1 antibody; Zeta chain associated protein kinase 70kDa isoform 2 antibody; Zeta chain of T cell receptor associated protein kinase 70 antibody; Zeta chain TCR associated protein kinase 70kD antibody; Zeta chain TCR associated protein kinase 70kDa antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P43403

Immunogen:Peptide sequence around aa.491~495 (S-Y-Y-T-A) derived from Human ZAP70.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:200

Background:ZAP70 is a 70-kD tyrosine phosphoprotein that associates with the zeta chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural KILLER cells. Protein-Tyrosine Kinases (PTKs) play an integral role in T-cell activation. Stimulation of the T-cell antigen receptor results in tyrosine phosphorylation of a number of cellular substrates. One of these is the TCR-zeta chain, which can mediate the transduction of extracellular stimuli into cellular effector functions

Chan AC, et al. (1995) EMBO J; 14(11): 2499-2508
Kong G, et al. (1996) Mol Cell Biol; 16(9): 5026-5035
Salomon AR, et al. (2003)Proc Natl Acad Sci U S A; 100(2): 443-448

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ZAP70

Research Areas:Tags & Cell Markers?Immunology;Signal transduction