XRCC3 Antibody - Cat. #: CSB-PA868959

SKU: CSB-PA868959

Size :100ul

Clone Number:

Aliases:CMM6 antibody; DNA repair protein XRCC3 antibody; RAD51 like antibody; X ray repair complementing defective repair in Chinese hamster antibody; X ray repair complementing defective repair in Chinese hamster cells 3 antibody; X ray repair cross complementing protein 3 antibody; X-ray repair cross-complementing protein 3 antibody; XRCC 3 antibody; XRCC3 antibody; XRCC3_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O43542

Immunogen:Synthesized peptide derived from Internal of Human XRCC3.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.

Hitoshi Kurumizaka, Nucleic Acids Res., Jul 2003; 31: 4041 - 4050.
Anna Renglin Lindh, Hum. Mol. Genet., Apr 2006; 15: 1217 - 1224.
Zhi-Yuan Xu, J. Pharmacol. Exp. Ther., Aug 2005; 314: 495 - 505.
Nazumi Alice Yamada, J. Biol. Chem., May 2004; 279: 232

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:XRCC3

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Metabolism