XAF1 Antibody, Biotin conjugated - Cat. #: CSB-PA764111LD01HU

SKU: CSB-PA764111LD01HU

Size :50ug

Clone Number:

Aliases:BIRC 4 binding protein antibody; BIRC4 binding protein antibody; BIRC4-binding protein antibody; BIRC4BP antibody; HSXIAPAF 1 antibody; HSXIAPAF1 antibody; XAF 1 antibody; XAF1 antibody; XAF1_HUMAN antibody; XIAP associated factor 1 antibody; XIAP-associated factor 1 antibody; XIAPAF1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q6GPH4

Immunogen:Recombinant Human XIAP-associated factor 1 protein (172-259AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:XAF1

Research Areas:Cell biology