X Antibody, Biotin conjugated - Cat. #: CSB-PA526046LD01HVP

SKU: CSB-PA526046LD01HVP

Size :50ug

Clone Number:

Aliases:X antibody; Protein X antibody; HBx antibody; Peptide X antibody; pX antibody

Product Type:Polyclonal Antibody

Immunogen Species:Hepatitis B virus genotype D

UniProt ID:O93195

Immunogen:Recombinant Hepatitis B virus genotype D Protein X protein (1-154AA)

Raised in:Rabbit

Species Reactivity:Hepatitis B virus genotype D

Tested Applications:ELISA

Background:Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:X

Research Areas:Others