WAS Monoclonal Antibody

SKU: BT-MCA2067

Size:100μL

Background:The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

Research_area:Signal Transduction

Target_protein:WAS

applications:IHC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:7B10E4

Host:Mouse

Isotype:Mouse IgG2a

Gene Symbol/ Name:WAS

Immunogen:Purified recombinant fragment of human WAS (AA: 57-170) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide.

Concentration:

Molecular weight(Da):53kDa

UniProt accession:P42768

Synonyms:THC, IMD2, SCNX, THC1, WASP

GeneID:7454