vpx Antibody, HRP conjugated - Cat. #: CSB-PA323941HB01SHD

SKU: CSB-PA323941HB01SHD

Size :50ug

Clone Number:

Aliases:vpxProtein Vpx antibody; Viral protein X antibody; X ORF protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Simian immunodeficiency virus (isolate PBj14/BCL-3) (SIV-sm) (Simian immunodeficiency virus sooty mangabey monkey)

UniProt ID:P19508

Immunogen:Recombinant Simian immunodeficiency virus Protein Vpx protein (1-112AA)

Raised in:Rabbit

Species Reactivity:Simian immunodeficiency virus

Tested Applications:ELISA

Background:Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:vpx

Research Areas:Others