vpx Antibody, FITC conjugated - Cat. #: CSB-PA356976LC01HLZ

SKU: CSB-PA356976LC01HLZ

Size :50ul

Clone Number:

Aliases:vpxProtein Vpx antibody; Viral protein X antibody; X ORF protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human) immunodeficiency virus type 2 subtype A

UniProt ID:P06939

Immunogen:Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-112AA)

Raised in:Rabbit

Species Reactivity:Human immunodeficiency virus type 2 subtype A

Tested Applications:

Background:Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:vpx

Research Areas:N/A