ULK3 Antibody - Cat. #: CSB-PA750879ESR1HU

SKU: CSB-PA750879ESR1HU

Size :50ul

Clone Number:

Aliases:DKFZP434C131 antibody; FLJ90566 antibody; Serine/threonine-protein kinase ULK3 antibody; Ulk3 antibody; ULK3_HUMAN antibody; unc 51 like kinase 3 (C. elegans) antibody; Unc-51-like kinase 3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q6PHR2

Immunogen:Recombinant Human Serine/threonine-protein kinase ULK3 protein (44-240AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ULK3

Research Areas:Signal transduction