ULBP2 Antibody - Cat. #: CSB-PA880151ESR1HU

SKU: CSB-PA880151ESR1HU

Size :50ul

Clone Number:

Aliases:ALCAN alpha antibody; ALCAN-alpha antibody; N2DL 2 antibody; N2DL-2 antibody; N2DL2 antibody; N2DL2_HUMAN antibody; NKG2D ligand 2 antibody; NKG2D ligand 2 precursor antibody; NKG2DL2 antibody; RAET1H antibody; Retinoic acid early transcript 1 H antibody; Retinoic acid early transcript 1H antibody; UL16 binding protein 2 antibody; UL16-binding protein 2 antibody; ULBP2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9BZM5

Immunogen:Recombinant Human NKG2D ligand 2 protein (26-216AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ULBP2

Research Areas:Immunology