TPX2 Antibody, HRP conjugated - Cat. #: CSB-PA892151LB01HU

SKU: CSB-PA892151LB01HU

Size :50ug

Clone Number:

Aliases:C20ORF1 antibody; C20orf2 antibody; Chromosome 20 Open Reading Frame 1 antibody; Differentially expressed in cancerous and non-cancerous lung cells 2 antibody; Differentially expressed in cancerous and noncancerous lung cells 2 antibody; Differentially expressed in lung cells 2 antibody; Differentially expressed in lung cells antibody; DIL 2 antibody; DIL-2 antibody; DIL2 antibody; FLS353 antibody; GD:C20orf1 antibody; HCA 519 antibody; HCA519 antibody; HCTP 4 antibody; HCTP4 antibody; Hepatocellular carcinoma associated antigen 519 antibody; Hepatocellular carcinoma-associated antigen 519 antibody; p100 antibody; Preferentially expressed in colorectal cancer antibody; Protein fls353 antibody; REPP 86 antibody; repp86 antibody; Restricted expression proliferation associated protein 100 antibody; Restricted expression proliferation-associated protein 100 antibody; Targeting protein for Xklp2 antibody; TPX 2 antibody; TPX2 antibody; TPX2 microtubule associated homolog antibody; TPX2 microtubule associated protein homolog antibody; TPX2 microtubule nucleation factor antibody; TPX2_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9ULW0

Immunogen:Recombinant Human Targeting protein for Xklp2 protein (160-320AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at \'Thr-288\' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TPX2

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology