Tp53 Antibody, Biotin conjugated - Cat. #: CSB-PA15509D0Rb

SKU: CSB-PA15509D0Rb

Size :50ug

Clone Number:

Aliases:Tp53 antibody; P53 antibody; Cellular tumor antigen p53 antibody; Tumor suppressor p53 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Rattus norvegicus (Rat)

UniProt ID:P10361

Immunogen:Recombinant Rat Cellular tumor antigen p53 protein (1-391AA)

Raised in:Rabbit

Species Reactivity:Rat

Tested Applications:ELISA

Background:Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression By similarity. Interacts with GRK5

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:Tp53

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology