TNK2 (Ab-284) Antibody - Cat. #: CSB-PA117710

SKU: CSB-PA117710

Size :100ul

Clone Number:

Aliases:Acetate kinase 1 antibody; Acetokinase 1 antibody; ACK 1 antibody; ACK antibody; ACK-1 antibody; ACK1 antibody; ACK1_HUMAN antibody; Activated Cdc42 associated kinase 1 antibody; Activated CDC42 kinase 1 antibody; Activated p21cdc42Hs kinase antibody; FLJ44758 antibody; FLJ45547 antibody; p21cdc42Hs antibody; TNK 2 antibody; TNK2 antibody; Tyrosine kinase non receptor 2 antibody; Tyrosine kinase non receptor protein 2 antibody; Tyrosine kinase non-receptor protein 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q07912

Immunogen:Synthesized peptide derived from Internal of Human ACK1.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.

Manser E., Nature 363:364-367(1993) [PubMed: 8497321].
Ota T.,Nat. Genet. 36:40-45(2004) [PubMed: 14702039].
Muzny D.M., Nature 440:1194-1198(2006) [PubMed: 16641997].

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TNK2

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Signal transduction