TNFRSF1A Monoclonal Antibody

SKU: BT-MCA3946

Size:100μL

Background:This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.

Research_area:Cell Biology

Target_protein:TNFRSF1A

applications:ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:2G11C9

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:TNFRSF1A

Immunogen:Purified recombinant fragment of human TNFRSF1A (AA: extra 30-211) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):51KDa

UniProt accession:P19438

Synonyms:FPF, p55, p60, TBP1, TNF-R, TNFAR, TNFR1, p55-R, CD120a, TNFR55, TNFR60, TNF-R-I, TNF-R55

GeneID:7132