TIMP1 Antibody - Cat. #: CSB-PA152790

SKU: CSB-PA152790

Size :100ul

Clone Number:

Aliases:Clgi antibody; Collagenase inhibitor antibody; Collagenase inhibitor; Human antibody; EPA antibody; EPO antibody; Erythroid Potentiating Activity antibody; Erythroid-potentiating activity antibody; Fibroblast collagenase inhibitor antibody; FLJ90373 antibody; HCI antibody; Human Collagenase Inhibitor antibody; Metalloproteinase inhibitor 1 antibody; Metalloproteinase inhibitor 1 precursor antibody; OTTHUMP00000023214 antibody; TIMP 1 antibody; TIMP antibody; TIMP metallopeptidase inhibitor 1 antibody; TIMP-1 antibody; Timp1 antibody; TIMP1 protein antibody; TIMP1_HUMAN antibody; Tissue Inhibitor of Metalloproteinase 1 antibody; Tissue inhibitor of metalloproteinases 1 antibody; Tissue inhibitor of metalloproteinases antibody; Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P01033

Immunogen:Synthesized peptide derived from internal of Human TIMP1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

Anieta M. Sieuwerts, Clin. Chem., May 2007; 10.1373.
KM Fong, Clin. Cancer Res., Aug 1996; 2: 1369.
E. Susol, Rheumatology, Dec 2000; 39: 1332 - 1336.
Christopher J Jackson, Ann Rheum Dis, Mar 1998; 57: 158 - 161.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TIMP1

Research Areas:Cancer?Cardiovascular?Cell biology;Signal transduction