TH (Ab-31) Antibody - Cat. #: CSB-PA695636

SKU: CSB-PA695636

Size :100ul

Clone Number:

Aliases:Dystonia 14 antibody; DYT14 antibody; DYT5b antibody; EC 1.14.16.2 antibody; OTTHUMP00000011225 antibody; OTTHUMP00000011226 antibody; ple antibody; Protein Pale antibody; TH antibody; The antibody; TY3H_HUMAN antibody; TYH antibody; Tyrosine 3 hydroxylase antibody; Tyrosine 3 monooxygenase antibody; Tyrosine 3-hydroxylase antibody; Tyrosine 3-monooxygenase antibody; Tyrosine hydroxylase antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P07101

Immunogen:Peptide sequence around aa.29~33(V-T-S-P-R)derived from Mouse Tyrosine Hydroxylase.

Raised in:Rabbit

Species Reactivity:Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the neurotransmitter dopamine and other catecholamines. TH functions as a tetramer, with each subunit composed of a regulatory and catalytic domain, and exists in several different isoforms . This enzyme is required for embryonic development since TH knockout mice die before or at birth . Levels of transcription, translation and posttranslational modification regulate TH activity. The amino-terminal regulatory domain contains three serine residues: Ser9, Ser31 and Ser40. Phosphorylation at Ser40 by PKA positively regulates the catalytic activity of TH . Phosphorylation at Ser31 by CDK5 also increases the catalytic activity of TH through stabilization of TH protein levels.

Kumer, S.C. and Vrana, K.E. (1996) J Neurochem 67, 443-62.
Bodeau-P

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TH

Research Areas:Neuroscience?Cancer;Metabolism