TAB2(Phospho-Ser372) Rabbit Polyclonal Antibody

SKU: BT-AP12946

Size:100μL

Background:The protein encoded by this gene is an activator of MAP3K7/TAK1| which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6| MAP3K7 and TAB1| and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein| along with TAB1 and MAP3K7| also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK)| which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects| multiple types| 2 (CHTD2). Alternative splicing results in multiple transcript variants.

Research_area:Signal transduction; Immunology

Target_protein:TAB2

applications:WB

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:TAB2

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: Q9NYJ8; Mouse: Q99K90; Rat: Q5U303

Synonyms:TAB2 ;Ser372 ; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TAB-2; TGF-beta-activated kinase 1-binding protein 2

GeneID:Human: 23118; Mouse: 68652; Rat: 308267