STIL Polyclonal Antibody

SKU: E-AB-40237

Size: 100μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: STIL

Target Synonym: DKFZp686O09161;MCPH7;OTTHUMP00000009566;SCL interrupting locus protein;SCL-interrupting locus protein;SCL/TAL1 interrupting locus;SIL;STIL;STIL_HUMAN;TAL 1 interrupting locus protein;TAL-1-interrupting locus protein

Research Areas: Cell Biology;Stem Cells

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q15468

Accession:

Background: This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.

Concentration: 1 mg/mL

Immunogen: Recombinant Human SCL-interrupting locus protien

Buffer: PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4

Purification method: Antigen Affinity Purification

Dilution: IHC 1:50-1:200

Calculated MW:

ObservedMW: