STAT3 antibody , Cat. # FNab08300

SKU: FNab08300

Size:100ug

Purification:Protein A+G purification

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Mouse

Clonality:monoclonal

Clone ID:6A9

Isotype:IgG2a

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene(PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6(IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1(PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation(By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation(PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. This antibody is a mouse monoclonal antibody raised against residues near the N terminus of human STAT3.

Immunogen:signal transducer and activator of transcription 3(acute-phase response factor)

Synonyms:Acute phase response factor, APRF, FLJ20882, HIES, STAT3

Observed MW:88 kDa

Uniprot ID:P40763

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC, IF, IP

Recommended dilution:WB: 1:2000-1:20000; IP: 1:1000-1:10000; IHC: 1:50-1:500; IF: 1:50-1:500

Gene ID:6774

Research Area:Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Developmental biology, Stem Cells