STAT1 Polyclonal Antibody

SKU: E-AB-32977

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: Stat1

Target Synonym: Signal transducer and activator of transcription 1 91kD;CANDF7;DKFZp686B04100;IMD31A;IMD31B;IMD31C;ISGF 3;ISGF-3;OTTHUMP00000163552;OTTHUMP00000165046;OTTHUMP00000165047;OTTHUMP00000205845;Signal transducer and activator of transcription 1 91kDa;Signal transducer and activator of transcription 1;Signal transducer and activator of transcription 1;91kD;Signal transducer and activator of transcription 1-alpha/beta;STAT 1;Stat1;STAT1;STAT91;Transcription factor ISGF 3 components p91 p84;Transcription factor ISGF-3 components p91/p84

Research Areas: Cancer;Epigenetics and Nuclear Signaling;Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: WB;IHC-p;IF

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P42224

Accession:

Background: Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.

Concentration: 1 mg/mL

Immunogen: Synthesized peptide derived from human Stat1 around the non-phosphorylation site of Ser727.

Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Purification method: Affinity purification

Dilution: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:50-1:200

Calculated MW: 87kDa

ObservedMW: 87kDa