SRGAP3 Polyclonal Antibody

SKU: E-AB-11600

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: SRGAP3

Target Synonym: ARHGAP 14;ARHGAP14;Gbi;ME GAP;MEGAP;Mental disorder associated GAP;Mental disorder-associated GAP;Rho GTPase activating protein 14;Rho GTPase-activating protein 14;SLIT ROBO Rho GTPase activating protein 3;SLIT-ROBO Rho GTPase-activating protein 3;srGAP 2;srGAP 3;srGAP2;srGAP3;SRGP 2;SRGP2;SRGP3;WAVE associated Rac GTPase activating protein;WAVE-associated Rac GTPase-activating protein;WRP

Research Areas: Neuroscience;Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: O43295

Accession:

Background: SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.

Concentration: 0.6 mg/mL

Immunogen: Recombinant protein of human SRGAP3

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: IHC 1:25-1:100

Calculated MW:

ObservedMW: