SPTN2 Rabbit Polyclonal Antibody

SKU: BT-AP04875

Size:100μL

Background:Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2)| is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to| but distinct from| the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia| SCA5| that is characterized by neurodegeneration| progressive locomotor incoordination| dysarthria| and uncoordinated eye movements.

Research_area:Neuroscience

Target_protein:SPTBN2

applications:WB

Reactivity:Human, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:SPTN2

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):262900

UniProt accession:Human: O15020; Rat: Q9QWN8

Synonyms:SPTN2

GeneID:Human: 6712; Rat: 29211