SPRTN Antibody - Cat. #: CSB-PA863937LA01HU

SKU: CSB-PA863937LA01HU

Size :50ug

Clone Number:

Aliases:SPRTN antibody; C1orf124 antibody; DVC1 antibody; UNQ1880/PRO4323 antibody; SprT-like domain-containing protein Spartan antibody; DNA damage protein targeting VCP antibody; DVC1 antibody; Protein with SprT-like domain at the N terminus antibody; Spartan antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9H040

Immunogen:Recombinant Human SprT-like domain-containing protein Spartan protein (1-239AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Regulator of UV-induced DNA damage response: acts as a \'reader\' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SPRTN

Research Areas:Epigenetics and Nuclear Signaling