SORL1 Monoclonal Antibody

SKU: BT-MCA4098

Size:100μL

Background:SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

Research_area:Signal transduction, Neuroscience

Target_protein:SORL1

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:7D7B11

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:SORL1

Immunogen:Purified recombinant fragment of SORL1 (aa2159-2214) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):

UniProt accession:Q92673

Synonyms:SORL1

GeneID:6653