SOCS1 Antibody - Cat. #: CSB-PA022388LA01HU

SKU: CSB-PA022388LA01HU

Size :50ug

Clone Number:

Aliases:CISH 1 antibody; CISH1 antibody; Cytokine inducible SH2 protein 1 antibody; JAB antibody; JAK binding protein antibody; JAK-binding protein antibody; Janus kinase binding protein antibody; SOCS 1 antibody; SOCS-1 antibody; Socs1 antibody; SOCS1_HUMAN antibody; SSI 1 antibody; SSI-1 antibody; SSI1 antibody; STAT induced STAT inhibitor 1 antibody; STAT-induced STAT inhibitor 1 antibody; Suppressor of cytokine signaling 1 antibody; Supressor of cytokine signalling 1 antibody; TEC interacting protein 3 antibody; Tec-interacting protein 3 antibody; TIP 3 antibody; TIP-3 antibody; TIP3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O15524

Immunogen:Recombinant Human Suppressor of cytokine signaling 1 protein (1-211AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival By similarity. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SOCS1

Research Areas:Epigenetics and Nuclear Signaling; Immunology; Signal transduction