SMAD1 Monoclonal Antibody

SKU: BT-MCA4665

Size:100μL

Background:The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Research_area:Signal Transduction

Target_protein:SMAD1

applications:WB

Reactivity:Human, Mouse, Rat

Clonality:Monoclonal

Clone ID:3C4G6

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:SMAD1

Immunogen:Purified recombinant fragment of human SMAD1 (AA: 1-110) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):52.3kDa

UniProt accession:Q15797

Synonyms:BSP1, JV41, BSP-1, JV4-1, MADH1, MADR1

GeneID:4086