SKA2 Antibody - Cat. #: CSB-PA823890LA01HU

SKU: CSB-PA823890LA01HU

Size :50ug

Clone Number:

Aliases:FAM33A antibody; Family with sequence similarity 33; member A antibody; FLJ12758 antibody; MGC110975 antibody; Protein FAM33A antibody; SKA 2 antibody; SKA2 antibody; SKA2_HUMAN antibody; Spindle and kinetochore associated complex subunit 2 antibody; Spindle and kinetochore associated protein 2 antibody; Spindle and kinetochore-associated protein 2 antibody; Spindle and KT (kinetochore) associated 2 antibody; Spindle and KT associated 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8WVK7

Immunogen:Recombinant Human Spindle and kinetochore-associated protein 2 protein (1-121AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Background:Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SKA2

Research Areas:Cell biology