SIRT5 antibody , Cat. # FNab07883

SKU: FNab07883

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins(PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting(PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species(PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2(By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c(CYCS) and a number of other proteins in vitro such as UOX.

Immunogen:sirtuin(silent mating type information regulation 2 homolog) 5

Synonyms:FLJ36950, SIR2 like protein 5, SIR2L5, SIRT5

Observed MW:33 kDa

Uniprot ID:Q9NXA8

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IP

Recommended dilution: WB: 1:500-1:1000; IP: 1:500-1:1000; IF: 1:50-1:500

Gene ID:

Research Area:Epigenetics, Metabolism