SERPINE1 Antibody, Biotin conjugated - Cat. #: CSB-PA11239D0Rb

SKU: CSB-PA11239D0Rb

Size :50ug

Clone Number:

Aliases:Clade E antibody; Endothelial plasminogen activator inhibitor antibody; Nexin antibody; Nexin plasminogen activator inhibitor type 1 antibody; PAI 1 antibody; PAI antibody; PAI-1 antibody; PAI1_HUMAN antibody; PLANH1 antibody; Plasminogen activator inhibitor 1 antibody; Plasminogen activator inhibitor type 1 antibody; Serine (or cysteine) proteinase inhibitor antibody; Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1 antibody; Serine proteinase inhibitor clade E member 1 antibody; serpin antibody; Serpin E1 antibody; Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1 antibody; Serpin peptidase inhibitor clade E antibody; Serpine 1 antibody; SERPINE1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P05121

Immunogen:Recombinant Human Plasminogen activator inhibitor 1 protein (24-398AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SERPINE1

Research Areas:Cancer; Cardiovascular; Cell biology; Metabolism