SAE1 Monoclonal Antibody

SKU: AN200081P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:SAE1

Target Synonym:AOS;SUA;SAE;AOS1;SUA1;UBLE1A;SAE1;Activator of SUMO1;HSPC140;Sentrin/SUMO activating protein AOS1;SUMO 1 activating enzyme E1 N subunit;SUMO 1 activating enzyme subunit 1;SUMO-activating enzyme subunit 1;Ubiquitin like protein SUMO1 activating enzyme;Ubiquitin-like 1-activating enzyme E1A;UBL E1A

Research Areas:Cell Biology

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:ICC/IF

Isotype:IgG2b

Clonality:Monoclonal

Clone NO.:2D8

UNIProt ID:Q9UBE0

Accession:

Background:SAE1 belongs to the ubiquitin-activating E1 family. It is a heterodimer that acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It functions as a UBLI E1 ligase mediating the ATP-dependent activation of UBL1. SAE1 binds with UBLE1A and UBLE1B to form a heterodimer which can bind UBL1. SAE1 also regulates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins.

Concentration:1 mg/mL

Immunogen:Recombinant Human SAE1 protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:ICC/IF 1:20-1:100;

Calculated MW:

ObservedMW: