RSPO3 Antibody, HRP conjugated - Cat. #: CSB-PA887154LB01HU

SKU: CSB-PA887154LB01HU

Size :50ug

Clone Number:

Aliases:CRISTIN1 antibody; hPWTSR antibody; hRspo3 antibody; Protein with TSP type-1 repeat antibody; PWTSR antibody; R-spondin 3 homolog antibody; R-spondin-3 [Precursor] antibody; R-spondin-3 antibody; Roof plate specific spondin-3 antibody; Roof plate-specific spondin-3 antibody; RSPO3 antibody; RSPO3_HUMAN antibody; Thrombospondin type I domain containing 2 antibody; Thrombospondin type-1 domain-containing protein 2 antibody; THSD2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9BXY4

Immunogen:Recombinant Human R-spondin-3 protein (22-272AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RSPO3

Research Areas:Developmental biology; Stem cells