ROBO4 Antibody - Cat. #: CSB-PA121728

SKU: CSB-PA121728

Size :50ul

Clone Number:

Aliases:ECSM4 antibody; FLJ20798 antibody; Magic roundabout antibody; MGC133352 antibody; MGC133353 antibody; MRB antibody; Robo 4 antibody; ROBO4 antibody; ROBO4_HUMAN antibody; Roundabout homolog 4 antibody; Roundabout homolog 4 magic roundabout antibody; Roundabout homolog 4 Precursor antibody; Roundabout, axon guidance receptor, homolog 4 (Drosophila) antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8WZ75

Immunogen:Fusion protein of Human ROBO4

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:25-1:100

Background:Robo4 (roundabout homolog 4 or magic roundabout) is a receptor for Slit proteins which implicate in angiogenesis and vascular patterning especially through facilitating inhibition of primary endothelial cell migration. It is a fairly recently identified member of Robo family and is shorter than other Robo members at both intracellular as well as extracellular domains. Robo4 plays important roles in several aspects of vascular development such as the guidance of endothelial cell migration, cell cycle regulation, inhibition of pathologic angiogenesis and endothelial hyperpermeability etc. Employing mouse and zebrafish models, Slit2/Robo4 interactions have been shown to maintain integrity of vascular network and its barrier function by inhibiting cytokine-mediated vasculogenesis with enhanced permeability, and that Slit2-Robo4-paxillin-GIT1 network inhibits neovascularization and vascular leakage. Moreover, single nucleotide polymorphorism of Robo4 has been documented to be associated with autism suggesting its role in development and function of human brain.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ROBO4

Research Areas:Neuroscience?Cancer?Cardiovascular