RO52 Polyclonal Antibody

SKU: BT-AP13871

Size:100μL

Background:This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.

Research_area:Epigenetics and nuclear signaling; Immunology

Target_protein:TRIM21

applications:WB, ELISA

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:E3 ubiquitin-protein ligase TRIM21

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: P19474; Mouse: Q62191

Synonyms:E3 ubiquitin-protein ligase TRIM21 ;EC 6.3.2.-;52 kDa Ro protein;52 kDa ribonucleoprotein autoantigen Ro/SS-A;RING finger protein 81;Ro;SS-A;Sjoegren syndrome type A antigen;SS-A;Tripar

GeneID:Human: 6737