RNF43 Antibody - Cat. #: CSB-PA019892LA01HU

SKU: CSB-PA019892LA01HU

Size :50ug

Clone Number:

Aliases:RNF43 antibody; E3 ubiquitin-protein ligase RNF43 antibody; EC 2.3.2.27 antibody; RING finger protein 43 antibody; RING-type E3 ubiquitin transferase RNF43 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q68DV7

Immunogen:Recombinant Human E3 ubiquitin-protein ligase RNF43 protein (566-697AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:500-1:1000

Background:E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RNF43

Research Areas:Cancer; Cell biology; Immunology