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Gene Bio Systems

RNF31 Antibody, FITC conjugated - Cat. #: CSB-PA856927LC01HU

RNF31 Antibody, FITC conjugated - Cat. #: CSB-PA856927LC01HU

CSB-PA856927LC01HU

€334,95 EUR
€334,95 EUR
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Size :50ug

Clone Number:

Aliases:E3 ubiquitin protein ligase RNF31 antibody; FLJ10111 antibody; FLJ23501 antibody; HOIL 1L interacting protein antibody; HOIL-1-interacting protein antibody; HOIL1L interacting protein antibody; HOIP antibody; RING finger protein 31 antibody; RNF31 antibody; RNF31_HUMAN antibody; ZIBRA antibody; Zinc in between ring finger ubiquitin associated domain antibody; Zinc in-between-RING-finger ubiquitin-associated domain protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96EP0

Immunogen:Recombinant Human E3 ubiquitin-protein ligase RNF31 protein (421-700AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear (\\\'Met-1\\\'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RNF31

Research Areas:Epigenetics and Nuclear Signaling; Cell biology

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