RFA2 Monoclonal Antibody

SKU: BT-MCA2782

Size:100μL

Background:This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways.

Research_area:Others

Target_protein:RFA2

applications:WB, IHC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:2C5B6

Host:Mouse

Isotype:Mouse IgG1,kappa

Gene Symbol/ Name:RFA2

Immunogen:Purified recombinant fragment of human RFA2 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):29kDa

UniProt accession:P15927

Synonyms:RP-A p34, RPA2, REPA2, RPA32, RPA34

GeneID:6118