Recombinant XBP1 Monoclonal Antibody

SKU: AN301006L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:XBP1

Target Synonym:CBX;X-box-binding protein;Tax responsive element binding protein;Tax-responsive element-binding protein;XBP;XBP1;TREB-5;TREB5;XBP-1;XBP2;XBP1s;CBX1;Tax responsive element binding protein 5;Tax-responsive element-binding protein 5;X box binding protein 1;X box binding protein 2;X-box-binding protein 1;XBP 1

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:12B12

UNIProt ID:P17861

Accession:

Background:This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human XBP1 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:200-1:1000;WB 1:1000-1:5000

Calculated MW:29 kDa

ObservedMW:35 kDa,60 kDa