Recombinant TGF beta 1 Monoclonal Antibody

SKU: AN301902L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:TGF beta 1

Target Synonym:DPD;Transforming growth factor beta;TGF-B;TGFB1;CED;DPD1;LAP;TGFB;TGFbeta;TGF-β;Cartilage-inducing factor;Differentiation inhibiting factor;IBDIMDE;TGF-B1;TGF-beta 1;TGF-beta-1;TGF-β1;Transforming growth factor beta-1 proprotein;Latency-associated peptide;Transforming growth factor beta-1;beta 1;Prepro transforming growth factor beta 1;TGF beta;TGF beta 1;TGF beta 1 protein;Tgfb-1;TGF-beta 1 protein;TGFbeta1;TGF-beta1;TGF-beta-5;transforming growth factor;Transforming Growth Factor b1;Transforming Growth Factor beta 1;Transforming growth factor beta 1a;Transforming Growth Factor-1

Research Areas:Signal Transduction;Stem Cells;Cancer;Metabolism;Cardiovascular;Cell Biology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A618

UNIProt ID:P01137

Accession:

Background:Transforming growth factor-β (TGF-β) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis. TGF-β elicits signaling through three cell surface receptors: type I (RI), type II (RII), and type III (RIII). Type I and type II receptors are serine/threonine kinases that form a heteromeric complex. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and activation of type I receptor kinases. The type III receptor, also known as betaglycan, is a transmembrane proteoglycan with a large extracellular domain that binds TGF-β with high affinity but lacks a cytoplasmic signaling domain. Expression of the type III receptor can regulate TGF-β signaling through presentation of the ligand to the signaling complex. The only known direct TGF-β signaling effectors are the Smad family proteins, which transduce signals from the cell surface directly to the nucleus to regulate target gene transcription.

Concentration:1 mg/mL

Immunogen:Recombinant human TGF beta 1 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000;IHC 1:500-1:1000

Calculated MW:44 kDa

ObservedMW:44, 10 kDa